I-Panthenol iphuma kwi-vitamin B5, eyaziwa ngokuba yi-retinol B5. I-Vitamin B5, eyaziwa ngokuba yi-pantothenic acid, ineepropati ezingazinzanga kwaye ichaphazeleka lula ngobushushu kunye nokuqulunqwa, okukhokelela ekunciphiseni kwe-bioavailability yayo. Ngoko ke, i-precursor yayo, i-panthenol, isoloko isetyenziselwa ukulungiswa kwezithambiso.
Xa kuthelekiswa ne-vitamin B5 / pantothenic acid, i-panthenol inezakhiwo ezizinzileyo kunye nesisindo se-molecular 205 kuphela. Inokungena ngokufanelekileyo kwi-stratum corneum kwaye iguqule ngokukhawuleza ibe yi-vitamin B5, eyona nxalenye ebalulekileyo ye-metabolism yomzimba kunye neyona nto ibalulekileyo eluhlaza. ukwenzela ukuhlanganiswa kwe-coenzyme A.ICoenzymeI-A yinto encedisayo kwiindlela ezahlukeneyo zokusabela kwe-enzyme emzimbeni. Ithatha inxaxheba kwimetabolism yamandla eselula, inika amandla kwimisebenzi yobomi bomzimba. Ukongeza, ikwathatha inxaxheba kwimetabolism yamacandelo abalulekileyo eluswini, njenge-cholesterol, i-fatty acids, kunye ne-sphingolipids synthesis.
Ukusetyenziswa kwe-panthenol kwisikhumba kwaqala ngo-1944 kwaye kunembali engaphezu kweminyaka engama-70. Isetyenziswa ikakhulu kwizithambiso zokuthambisa, ukuthambisa, kunye neenjongo zokulungisa.
Eyona ndima ibalulekileyo
Ukufumakunye nokuphucula imiqobo
I-Panthenol ngokwayo inemisebenzi yokufunxa ukufuma kunye nokugcina, ngelixa ikhuthaza i-lipid synthesis, inyusa i-fluidity yeemolekyuli ze-lipid kunye ne-keratin microfilaments, iphucula imeko eqinileyo phakathi kwe-keratinocytes, kunye nokunceda ukugcina umsebenzi wokuthintela ulusu olusempilweni. Kufuneka kuqatshelwe ukuba ukwenzela ukuba i-panthenol iphucule umphumo wokuthintela, ukugxininiswa kufuneka kube yi-1% okanye ngaphezulu, ngaphandle koko i-0.5% ingaba ngumphumo wokuthambisa.
Iyathuthuzela
Impembelelo epholisayo ye-panthenol ikakhulu ivela kwimiba emibini: ① ukhuseleko kumonakalo woxinzelelo lwe-oxidative ② ukuncitshiswa kwempendulo yokudumba.
① I-Panthenol inokunciphisa ukuveliswa kweentlobo ze-oksijini esebenzayo kwiiseli zolusu, ngelixa ilawula indlela ye-antioxidant yolusu, kuquka ukunyanzeliswa kweeseli zesikhumba ukuba zivakalise ngakumbi i-antioxidant factor - i-heme oxygenase-1 (HO-1), ngaloo ndlela iphucula i-antioxidant ye-Pantothenic acid. inokunciphisa impendulo yokuvuvukala. Emva kokuvuselela i-keratinocytes nge-capsaicin, ukukhululwa kwezinto ezivuthayo i-IL-6 kunye ne-IL-8 inyuka kakhulu. Nangona kunjalo, emva kokunyangwa nge-pantothenic acid, ukukhutshwa kwezinto ezivuthayo kunokuvinjelwa, ngaloo ndlela kuncitshiswe impendulo yokuvuvukala kunye nokunciphisa ukuvuvukala.
Yazisaukulungisa
Xa ukuxinwa kwe-panthenol kuphakathi kwe-2% kunye ne-5%, kunokukhuthaza ukuvuselelwa kwesikhumba somntu owonakele. Emva kokunyanga imodeli yokulimala kwe-laser kunye ne-panthenol, ukubonakaliswa kwe-Ki67, umakishi wokunyuka kwe-keratinocyte, kwanda, kubonisa ukuba i-keratinocyte eninzi yangena kwi-proliferative state kwaye ikhuthaza ukuvuselelwa kwe-epidermal. Okwangoku, ukubonakaliswa kwe-filaggrin, uphawu olubalulekileyo lokwahlula i-keratinocyte kunye nomsebenzi wokuthintela, nalo lwanda, lubonisa ukukhuthazwa kokulungiswa komqobo wesikhumba. Uphononongo olutsha ngo-2019 lubonise ukuba i-panthenol ikhuthaza ukuphiliswa kwesilonda ngokukhawuleza kuneoyile yeminerali kwaye inokuphucula izibazi.
Ixesha lokuposa: Aug-30-2024
