I-sodium hyaluronateifumaneka ngokubanzi kwizilwanyana nakubantu into esebenzayo ye-physiologically, kwisikhumba somntu, i-synovial fluid, i-umbilical cord, i-aqueous humor, kunye ne-ophthalmic vitreous body isasazwa. Ubunzima bayo bemolekyuli yi-500 000-730 000 Dalton. Isisombululo sayo sine-viscoelasticity ephezulu kunye neprofayili. Yinto encedisayo yotyando lwamehlo. Igcina ubunzulu obuthile begumbi langaphambili emva kwesitofu kwigumbi langaphambili. Ilungele ukusebenza. Ikwakhusela iiseli ze-corneal endothelial kunye nezicubu ze-intraocular, zinciphisa iingxaki zokusebenza, kwaye zikhuthaza ukuphulukiswa kwesilonda.
Umthombo weSodium hyaluronate
I-sodium hyaluronateI-macromolecule ye-polysaccharide ekhutshwe kumzimba we-bovine vitreous. Ineempawu ezintathu: ukuchasa ukuguga kunye nokugcinwa ngokutsha kunye nokwamkela iteknoloji yebhayoloji.
I-sodium hyaluronate yenye yamacandelo esikhumba somntu, yeyona asidi isasazwa kakhulu kwi-mucosa emzimbeni, ikhona kwi-matrix ye-connective tissue, kwaye inesiphumo esihle sokuthambisa.
Iimpawu zeSodium hyaluronate
I-sodium hyaluronate ineempawu ezintathu: ukuchaswa kokuguga kunye nokugcinwa ngokutsha kunye ne-biotechnology. I-sodium hyaluronate yenye yamacandelo esikhumba somntu kunye neyona mucose ene-asidi esasazwa kakhulu emzimbeni womntu. Ikhona kwi-matrix ye-tissue edibeneyo kwaye inefuthe elihle lokuthambisa.
Iinzuzo zeSodium Hyaluronate
1. Ukuphucula i-Pharmacodynamics
Hyaluronic acidlelona candelo liphambili lezicubu ezixhumeneyo ezifana ne-interstitium yomntu, i-vitreous body, kunye ne-synovial fluid. Ineempawu zokugcina amanzi, ukugcina indawo engaphandle, ukulawula uxinzelelo lwe-osmotic, i-lubricating, kunye nokukhuthaza ukulungiswa kweeseli kwi-vivo. Njengomthwali wamachiza e-ophthalmic, inokwandisa ixesha lokugcinwa kweziyobisi kumphezulu wamehlo ngokunyusa i-viscosity yamathontsi eliso, ukuphucula ukufumaneka kweziyobisi, kunye nokunciphisa ukucaphuka kwamachiza emehlweni.
Unyango lwe-adjuvant lunokuthi lufakwe ngokuthe ngqo kwi-articular cavity njenge-lubricant yonyango lwe-arthritis, njenge-injection ye-SPIT.
2. Crease Resistance
Inqanaba lokufuma kwesikhumba lihambelana ngokusondeleyo nomxholo we-hyaluronic acid. Ngokunyuka kweminyaka yobudala, umxholo we-hyaluronic acid esikhumbeni uyancipha, owenza buthathaka umsebenzi wokugcinwa kwamanzi kwesikhumba kwaye uvelise imibimbi. Isisombululo samanzi sesodium i-hyaluronate ine-viscoelasticity eyomeleleyo kunye ne-lubricity. Xa igalelwe kumphezulu wolusu, inokwenza ifilimu evumela ukufuma ukuze igcine ulusu lufumile kwaye lukhazimla. Imolekyuli encinci ye-hyaluronic acid inokungena kwidermis, ikhuthaze i-microcirculation yegazi, incede ulusu ukuba lufunxe izondlo, kwaye ludlale indima yezempilo yokuthambisa kunye nokuchasana nemibimbi.
3. Isiphumo sokufuma
Isiphumo sokuthambisa yeyona ndima ibalulekileyosodium hyaluronate kwizithambiso. Xa kuthelekiswa nezinye izinto zokuthambisa, ukufuma okunxulumene nendawo engqongileyo kunempembelelo encinci kwisiphumo sawo sokuthambisa. Olu hlobo lukhethekileyo lulungelelaniswa nolusu ngamaxesha ahlukeneyo, ukufuma okusingqongileyo okwahlukileyo, njengobusika obomileyo kunye nehlobo elimanzi, kunye neemfuno zokuthambisa isiphumo sokuthambisa. Ukugcinwa komswakama we-sodium hyaluronate kuhambelana nobunzima bayo kunye nobunzima bemolekyuli.
4. Iziphumo zesondlo
I-Sodium hyaluronate yinto engokwemvelo yebhayoloji eluswini, kwaye i-hyaluronate yangaphandle yesodium sisongezelelo kwi-endogenous sodium hyaluronate eluswini. I-hyaluronate ye-sodium enomgangatho ophantsi inokungena kwi-epidermis yesikhumba, ikhuthaze ukunikezelwa kwesondlo solusu kunye nokukhutshwa kwenkunkuma, ngaloo ndlela ikhusela ukuguga kwesikhumba, kwaye idlale indima kwi-cosmetology kunye nobuhle. Ukugcinwa kolusu kubaluleke ngakumbi kunezinye izithambiso kwaye kuye kwaba ngumnqweno wabantu banamhlanje ukugcina ukuqonda kobuso.
5. Ukulungiswa kunye nokuThintelwa komonakalo wolusu
Ulusu lutshiswa okanye lutshiswe kukukhanya kwelanga, njengokubomvu, ukwenza mnyama, ukuxobuka, njl., ikakhulu yimitha ye-ultraviolet ekukhanyeni kwelanga. I-sodium hyaluronate inokukhuthaza ukuvuselelwa kwesikhumba esonzakeleyo ngokukhuthaza ukwanda kunye nokwahlula kweeseli ze-epidermal kunye nokukhupha i-radicals-free radicals. Ukusetyenziswa kwangaphambili kunempembelelo yokuthintela. Indlela yokusebenza kwayo ihluke kwi-absorbent ye-ultraviolet esetyenziswa ngokuqhelekileyo kwi-sunscreen. Ngoko ke, i-hyaluronic acid kunye ne-ultraviolet i-absorbent kwiimveliso ze-sunscreen skincare zinefuthe le-synergistic, elinokunciphisa ukuhanjiswa kwemisebe ye-ultraviolet kunye nokulungisa umonakalo wesikhumba obangelwa inani elincinci lemitha ye-ultraviolet, ngaloo ndlela idlala indima yokukhusela kabini.
Ukudibanisa i-sodium hyaluronate kunye ne-EGF (i-epidermal growth factor) inokukhawulezisa ukuvuselelwa kweeseli ze-epidermal kwaye yenze ulusu lube luthenda, lulula kwaye lulula. Xa ulusu lubandezeleka ngokutshisa okuncinci kunye nokutshisa, ukusetyenziswa kwezithambiso zamanzi ezine-sodium hyaluronate kumphezulu kunokunciphisa intlungu kunye nokukhawuleza ukuphulukiswa kwesikhumba esonzakeleyo.
6. Ukuthanjiswa kunye noLwakhiwo lweFilimu
I-sodium hyaluronate luhlobo lwepolymer ene-lubrication eyomeleleyo kunye neempawu zokwenza ifilimu. Iimveliso ze-Skincare ezine-sodium hyaluronate zine-lubrication ecacileyo kunye nesandla esilungileyo xa sisetyenziswa. Xa ifakwe esikhumbeni, ifilimu inokuqulunqwa kumphezulu wolusu, okwenza ulusu luzive lucolile kwaye lufumile, kwaye lukhusela ulusu. Iimveliso zokhathalelo lweenwele ezine-sodium hyaluronate zinokwenza umaleko wefilimu kumphezulu weenwele, ezinokuthi zifume, zithambise, zikhusele iinwele, ziphelise umbane ongatshintshiyo, kwaye zenze iinwele zibe lula ukukama, ezintle, kunye nezendalo.
7. Ukutyeba
I-sodium hyaluronate ine-viscosity ephezulu kwisisombululo esinamanzi. Inokudlala indima yokuqina kunye nokuzinzisa kwizinto zokuthambisa.
8. Iziphumo ze-Pharmacological zeSodium Hyaluronate
Izinto ezisebenzayo zePhysiological zikho ngokubanzi kwizilwanyana nakubantu kwaye zisasazwa eluswini lomntu, ulwelo lwe-synovial lwamalungu, intambo ye-umbilical, i-aqueous humor, kunye ne-vitreous body of eyes. Ubunzima bemolekyuli yi-500000-730000 Dalton. Isisombululo sayo sine-viscoelasticity ephezulu kunye nokuxelisa. Yinto encedisayo yotyando lwamehlo. Igcina ubunzulu obuthile begumbi langaphambili emva kwesitofu kwigumbi langaphambili, elilungele ukusebenza. Ikwakhusela iiseli ze-corneal endothelial kunye nezicubu ze-intraocular, zinciphisa iingxaki, kwaye zikhuthaza ukuphulukiswa kwesilonda.
Ixesha lokuposa: Aug-23-2023
