I-DL-panthenol: Isitshixo esiPhambili sokuLungiswa koLusu

Kwinkalo yenzululwazi yezithambiso, i-DL panthenol ifana nesitshixo esivula umnyango kwimpilo yolusu. Esi sandulela sevithamin B5, kunye nokuthambisa kwayo okugqwesileyo, ukulungiswa, kunye neziphumo zokuchasa ukudumba, iye yaba sisithako esisebenzayo esiyimfuneko kwiifomula zokhathalelo lwesikhumba. Eli nqaku liza kuphonononga kwiimfihlakalo zesayensi, ixabiso lesicelo, kunye nethemba elizayo le-DL panthenol.

1, Ukwenziwa kwekhowudi yenzululwazi yeDL panthenol

I-DL panthenol yindlela ye-racemic ye-panthenol, enegama lekhemikhali i-2,4-dihydroxy-N - (3-hydroxypropyl) -3,3-dimethylbutanamide. Ulwakhiwo lwalo lwemolekyuli luneqela elinye eliphambili lotywala kunye namaqela amabini esibini otywala, nto leyo enika i-hydrophilicity egqwesileyo kunye nokungena.

Inkqubo yokuguqulwa kwesikhumba ngundoqo ekusebenzeni kwe-DL panthenol. Emva kokungena kwesikhumba, i-DL panthenol iguqulwa ngokukhawuleza ibe yi-pantothenic acid (i-vitamin B5), ethatha inxaxheba kwi-synthesis ye-coenzyme A, ngaloo ndlela ichaphazela i-fatty acid metabolism kunye nokwanda kweeseli. Uphando luye lwabonisa ukuba izinga lokuguqulwa kwe-DL panthenol kwi-epidermis linokufikelela kwi-85%.

Indlela ephambili yesenzo ibandakanya ukuphucula umsebenzi wokuthintela ulusu, ukukhuthaza ukwanda kweeseli ze-epithelial, kunye nokuthintela impendulo yokuvuvukala. Idatha yovavanyo ibonisa ukuba emva kokusebenzisa imveliso equkethe i-5% ye-DL panthenol kwiiveki ezi-4, ukulahlekelwa kwamanzi e-transdermal kwesikhumba kuncitshiswa ngama-40%, kwaye ingqibelelo ye-stratum corneum iphuculwe kakhulu.

2、 Ukusetyenziswa kwe-Multidimensional yeDL panthenol

Kwintsimi yokuthambisa, i-DL panthenol iphucula i-hydration ye-stratum corneum kwaye yandisa umthamo womswakama wesikhumba. Ulingo lwezonyango lubonise ukuba ukusebenzisa i-moisturizer equkethe i-DL panthenol kwiiyure ze-8 kwandisa umgangatho womswakama wesikhumba nge-50%.

Ngokumalunga nokulungiswa, i-DL panthenol inokukhuthaza ukwanda kweeseli ze-epidermal kunye nokukhawulezisa ukubuyiswa komsebenzi wokuthintela. Uphando luye lwabonisa ukuba ukusetyenziswa emva kokusebenza kweemveliso eziqukethe i-DL panthenol kunokunciphisa ixesha lokuphulukisa isilonda nge-30%.

Kukhathalelo lwemisipha ebuthathaka, i-DL panthenol's anti-inflammatory and soothing effects zibalaseleyo. Iimvavanyo zibonise ukuba i-DL panthenol inokuthintela ukukhutshwa kwezinto ezivuthayo ezifana ne-IL-6 kunye ne-TNF - α, ukunciphisa ubomvu besikhumba kunye nokucaphuka.

Ekunyamekelweni kweenwele, i-DL panthenol inokungena kwizinwele kwaye ilungise i-keratin eyonakele. Emva kokusebenzisa iimveliso zokunakekelwa kweenwele eziqukethe i-DL panthenol kwiiveki ze-12, amandla okuphuka kweenwele anyuke nge-35% kunye nokucwebezela kuphuculwe ngama-40%.

3, Amathuba exesha elizayo eDL panthenol

Ubuchwephesha obutsha bokuqulunqa obufana ne-nanocarriers kunye ne-liposomes buphucule kakhulu ukuzinza kunye ne-bioavailabilityDL panthenol. Ngokomzekelo, i-nanoemulsions inokunyusa ukunyanzeliswa kwesikhumba se-DL panthenol ngamaxesha angama-2.

Uphando lwesicelo seklinikhi luqhubeka lunzulu. Uphando lwamva nje lubonisa ukuba i-DL panthenol inexabiso elinokubakho kunyango lwe-adjuvant yezifo zesikhumba ezifana ne-atopic dermatitis kunye ne-psoriasis. Ngokomzekelo, ukusetyenziswa kwe-DL panthenol equkethe i-formulations kwizigulane ezine-atopic dermatitis kunokunciphisa amanqaku okurhawuzelela ngama-50%.

Ithemba lemarike libanzi. Kulindeleke ukuba ngo-2025, ubungakanani bemarike ye-DL panthenol yomhlaba wonke buya kufikelela kwi-350 yezigidi zeedola zase-US, kunye nezinga lokukhula ngonyaka ngaphezu kwe-8%. Ngokunyuka kwemfuno yezithako ezisebenzayo ezithambileyo ezivela kubathengi, iindawo zokusetyenziswa kwe-DL panthenol ziya kwandisa ngakumbi.

Ukufunyanwa kunye nokusetyenziswa kwe-DL panthenol kuye kwavula ixesha elitsha lokunakekelwa kwesikhumba. Ukusuka kumanzi kunye nokulungiswa ukuya kwi-anti-inflammatory and soothing, ukusuka ekunyamekelweni kobuso ukuya ekunyamekelweni komzimba, esi sithako esisebenzayo sitshintsha indlela esibona ngayo impilo yesikhumba. Kwixesha elizayo, kunye nokuqhubela phambili kobugcisa bokuqulunqa kunye nokujula kophando lweklinikhi, i-DL panthenol ngokungathandabuzekiyo iya kuzisa izinto ezintsha kunye namathuba okunyamekela ulusu. Endleleni yokuphishekela ubuhle kunye nempilo, i-DL panthenol iya kuqhubeka idlala indima ekhethekileyo kunye nebalulekileyo, ibhala isahluko esitsha kwisayensi yesikhumba.