I-Anti-inflammatory kunye ne-antioxidant indlela ene-pronged-pronged-indawo yokunyamekela ulusu lwendalo, i-phloretin!

1.-Yintoni i-phloretin-

I-Phloretin(Igama lesiNgesi: iPhloretin), ekwabizwa ngokuba yi-trihydroxyphenolacetone, yeye-dihydrochalcones phakathi kwe-flavonoids. Igxininiswe kwi-rhizomes okanye iingcambu zee-apula, i-strawberries, iipereyi kunye nezinye iziqhamo kunye nemifuno eyahlukeneyo. Ithiywe ngesikhumba. Inyibilika kwisisombululo sealkali, inyibilika ngokulula kwi-methanol, i-ethanol kunye ne-acetone, kwaye phantse ayinyibiliki emanzini.

I-Phloretin inokufunxwa ngokuthe ngqo ngumzimba womntu, kodwa kwizityalo, i-phloretin encinci kakhulu yendalo. I-Phloretin ubukhulu becala ikhona kwimo ye-glycoside derivative, i-phhlorizin. I-phloretin efunxwa ngumzimba womntu ikwi-gastric mucosa. Kuphela emva kokuba iqela le-glycoside lisuswe ukuvelisa i-phloretin inokungena kwinkqubo yokujikeleza kwaye isebenzise umphumo wayo.

Igama lomchiza: 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone

Ifomula yemolekyuli: C15H14O5

Ubunzima bemolekyuli: 274.27

2.-Imisebenzi ephambili ye-phloretin-

i-anti-oxidation

I-Flavonoids inomsebenzi we-anti-fat oxidation, oye waqinisekiswa kwasekuqaleni kwe-1960: izakhiwo ze-polyhydroxyl ze-flavonoids ezininzi zinokuba neempawu ezibalulekileyo ze-antioxidant ngokuhlanjululwa ngee-ion zetsimbi.

I-Phloretin yi-antioxidant yendalo egqwesileyo. Isakhiwo se-2,6-dihydroxyacetophenone sinesiphumo esihle kakhulu se-antioxidant. Unempembelelo ecacileyo kwi-scavenging peroxynitrite kwaye ine-concentration ephezulu ye-antioxidant kwioli. Phakathi kwe-10 kunye ne-30PPm, inokususa i-radicals yamahhala esikhumbeni. Umsebenzi we-antioxidant we-Phlorizin uyancipha kakhulu ngenxa yokuba iqela layo le-hydroxyl kwindawo ye-6 litshintshwa liqela le-glucosidyl.
Ukuthintela i-tyrosinase

I-Tyrosinase i-metalloenzyme ene-copper kwaye iyi-enzyme ephambili ekubunjweni kwe-melanin. Umsebenzi we-tyrosinase unokusetyenziselwa ukuvavanya ukuba ingaba imveliso inefuthe elimhlophe. I-Phloretin yi-reversible inhibitor edibeneyo ye-tyrosinase. Inokuthintela i-tyrosinase ekubopheni kwi-substrate yayo ngokuguqula isakhiwo sesibini se-tyrosinase, ngaloo ndlela inciphisa umsebenzi wayo wokuncedisa.

Umsebenzi we-Antibacterial

I-Phloretin yi-flavonoid compound kunye nomsebenzi we-antibacterial. Ineempembelelo zokuthintela kwiintlobo ngeentlobo zebhaktheriya zeGram-positive, iibhaktheriya zeGram-negative kunye nefungi.
Iziphumo zovavanyo lwezonyango zibonisa ukuba emva kokuba izifundo zisebenzise i-phloretin kwiiveki ze-4, i-whiteheads, i-blackheads, i-papules, kunye ne-sebum secretion yancitshiswa kakhulu, ebonisa ukuba i-phloretin inamandla okunciphisa i-acne.

3. Izithako ezicetyiswayo
undoqo
2% i-phloretin(i-antioxidant, mhlophe) + 10% [l-ascorbic acid] (i-antioxidant, ukukhuthazwa kwe-collagen kunye nomhlophe) + 0.5%acid ferulic(i-antioxidant kunye ne-synergistic effect), inokuxhathisa imisebe ye-ultraviolet kwindalo , i-radiation ye-infrared kunye nomonakalo we-ozone kwesikhumba, ikhanyise ithoni yesikhumba, kwaye ifaneleke ngakumbi kwesikhumba esinamafutha kunye nethoni epholileyo yesikhumba.